The ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial, an open-labeled, randomized study in persons 50 years or older with abnormal glucose levels (impaired fasting glucose and/or impaired glucose tolerance) or early type 2 diabetes mellitus and established cardiovascular (CV) disease or CV risk factors, comparing insulin glargine to standard care found the overall incidence of all types of cancer combined or death from cancers was similar between treatment groups (n=12,537). In July 2009, The US FDA reported on an ongoing safety review evaluating a possible increased risk of cancer. In February 2011, the FDA in an updated communication reported the evidence was inconclusive and it is not possible to conclude that the use of this insulin increases the risk of cancer. [ Ref ]
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The few times I tried to have two shakes a day I got sick. I could literally feel my insides working overtime and it made me run to the bathroom a lot and I felt weak and uncomfortable and nauseas. This is when I started to just do one shake a day and the two weeks I was doing this I felt the runs often and I was getting headaches, on the verge of migraines, every single day. When I wasn’t dealing with a headache I felt a headache coming. It was constant. I also had a very dry mouth and I was constantly drinking water. When I wasn’t drinking water I felt nauseas from how dry my mouth was. It wasn’t until I bought the protein bars and immediately got a headache that I put two and two together.