Methods of test classes basically replace the code of the test seam with the code of the test injection. The code of the test injection gets executed in the runtime context of the test seam. Consequently the code of the test injection has access to variables and members visible to the domain code only. Controversially the code in the test injection has no access to variables visible to the method with the injection. If you desire to pass content from the test class to the injected code you may consider the use of global variables. Although the test seams are declared within the domain code, they do not alter the behaviour of the domain code for the productive use case. Therefore test seams have not the smell of the anti-pattern “Test code in Production”.
Administration. Before starting this medication, test for allergy with a dose of oral paliperidone. Then administer 2 consecutive loading doses of paliperidone palmitate by deltoid IM injection; first 234 mg, and then a 156-mg dose after 7 to 10 days. Monthly injections of 117 mg are recommended, although higher or lower dosages can be used depending on the clinical situation. The first 2 injections should be in the deltoid muscle because plasma concentrations are 28% higher with deltoid vs gluteal administration. Subsequent injections can alternate between gluteal and deltoid sites.
In addition to data from the 2 phase III clinical trials, data from phase I/II studies were also included in the FDA review. In an open-label, 2-center, uncontrolled, randomized, phase I clinical trial, Rosenfeld and colleagues (2006) examined if multiple intravitreal doses of up to 2 mg of ranibizumab can be tolerated and are biologically active when injected using a dose-escalating strategy in eyes of patients with neovascular AMD. A total of 32 patients with primary or recurrent sub-foveal choroidal neovascularization secondary to AMD were enrolled. Baseline best-corrected VA in the study eye was from 20/40 to 20/640 (Snellen equivalent). Treatment regimens consisted of 5, 7, or 9 intravitreal injections of ranibizumab at 2- or 4-week intervals for 16 weeks, with escalating doses ranging from to mg. Patients were evaluated through day 140, 4 weeks after their last injection. Safety was assessed based on ocular and non-ocular adverse events, changes in VA, changes in intraocular pressure (IOP), slit-lamp ocular examination, changes in lesion characteristics based on fluorescein angiography and color fundus photography, and the presence of anti-ranibizumab antibodies. A total of 29 patients received an injection at baseline, and 27 patients completed the study through day 140. Results were similar across the 3 treatment groups. All patients experienced ocular adverse events, most of which were mild. The most common ocular adverse events were iridocyclitis (83 %), and injection-site reactions (72 %). Inflammation did not increase with repeated injections, despite the increasing ranibizumab doses. Transient mild IOP elevations were common after ranibizumab injection. No serum anti-ranibizumab antibodies were detected. In general, median and mean VAs in the study eyes improved by day 140 in all 3 groups. Only 3 of the 27 patients lost significant vision. There was no significant lesion growth, and a decrease in area of leakage from choroidal neovascularization was detected through day 140. The authors concluded that multiple intravitreal injections of ranibizumab at escalating doses ranging from to mg were well-tolerated and biologically active in eyes with neovascular AMD through 20 weeks. Mild transient ocular inflammation was the most common post-injection adverse event.