Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder. 
Because non-genomic pathways include any mechanism that is not a genomic effect, there are various non-genomic pathways. However, all of these pathways are mediated by some type of steroid hormone receptor found at the plasma membrane.  Ion channels, transporters, G-protein coupled receptors (GPCR), and membrane fluidity have all been shown to be affected by steroid hormones.  Of these, GPCR linked proteins are the most more information on these proteins and pathways, visit the steroid hormone receptor page.
Of course, we said there were two testosterone related Winstrol side-effects , the first being testosterone suppression and the second being testicular atrophy. As testosterone is manufactured in the testicles, when production is suppressed the testicles simply atrophy. They do not shrink and disappear; in-fact, in some cases the difference may not be all that noticeable. When we’re speaking of testicular atrophy we’re simply referring to the testicles losing some of their fullness. Once the use of all anabolic steroids has been discontinued and all the hormones are out of your system natural testosterone production will begin again, and your testicles will return to their normal size.