Hormone therapy can help relieve the symptoms of perimenopause and menopause. Hormone therapy means taking estrogen and, if you have never had a hysterectomy and still have a uterus, progestin . Progestin is a form of progesterone. Taking progestin helps reduce the risk of cancer of the uterus that occurs when estrogen is used alone. If you do not have a uterus, estrogen is given without progestin. Estrogen plus progestin sometimes is called “combined hormone therapy” or simply “hormone therapy.” Estrogen-only therapy sometimes is called “estrogen therapy.”
In premenopausal women the majority of estrogen produced by the body is estradiol (produced primarily in the ovaries), while in postmenopausal women estrone (produced in fat cells) is the type of estrogen present in the greatest amount; however, the body is able to convert one type of estrogen into another to a certain extent. Because of the limited research into potency, delivery methods and conversion of the various estrogens, a valid scientific understanding of compounded estrogen products has not been achieved.  Synthetic estradiol, taken orally, splits when absorbed in the gastrointestinal tract and delivers bioidentical estradiol to the bloodstream.