Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS ).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular Disorders: venous thromboembolism
Miscellaneous: Inflammation and pain at the site of intramuscular injection.
DEPO - Testosterone (testosterone cypionate injection) is an androgen indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone including, 1) Primary hypogonadism ( congenital or acquired ) - testicular failure due to cryptorchidism , bilateral torsion, orchitis , vanishing testis syndrome, or orchidectomy; and 2) Hypogonadotropic hypogonadism (congenital or acquired) - gonadotropin or LHRH deficiency, or pituitary -hypothalamic injury from tumors, trauma , or radiation . Common side effects of DEPO -Testosterone include: