A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
And finally, perhaps the most fundamental question of all: Even if female athletes with hyperandrogenism do have a unique and significant performance advantage, is it automatically unfair? At the end of the day, Karkazis believes that question is a social and cultural one. “It really is an open question about whether or not something is fair or unfair, leaving aside the science of it,” she said. “The science could still say there’s a link between [testosterone] and performance and we could still say, and that’s fine, it shouldn’t be understood as unfair.”
The derivatives of testosterone’s are called anabolics. This is when a testosterone is changed in a way that only keeps some of its original characteristics buts excludes others. For example a anabolic steroid could have muscle building effects but without the water retention of the original testosterone it got derived from. These variations are endless and a science on its own. We will discuss and explain every characteristic of every anabolic steroid in depth so that athletes would know what is best for them because we all have different needs.