It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
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Boldenone undecyclenate is generally injected every four or five days but some people will inject every day while others will inject once per week. The longer half-life of the undecyclenate ester would dictate an injection frequency of every 10-14 days but there has been a trend towards more frequent dosing by AAS users even with drugs known to have long half-lives. Dosing is generally kept pretty low (300-500 mgs per week) however the low binding affinity would argue for doses twice that which would be taken with testosterone. The anabolic to androgenic ratios are favorable for boldenone however people do not consider boldenone to be a particularly potent steroid, possibly due to the low doses that are utilized. Also, boldenone does not cause much water retention so many people assume it is not working if they do not put on ten pounds in one week. Boldenone is said to cause an increase in vascularity. There is no mechanism to explain why boldenone would do this anymore than any other AAS.